Hormone Implants
Wiki Index
This page is mostly focused on MTF estrogen implants, but there is also some information about other uses and types of implants (sometimes called pellets).
Related wiki pages
Resources on implants
reddit
Implant Insertion
Wikipedia
reddit
YouTube
Other
Papers
Implant Removal
Note that estrogen pellets do not need to be removed for SRS (GRS/GCS/etc).
YouTube
Cutting Implants
According to the 2018 West London Menopause and Premenstrual Syndrome Service Guidelines both estrogen and testosterone implants can be cut in half if a reduced dosage is required. Note that its very unlikely you'll be able to store and keep the other half.
Estrogen dose ... Low dose 25 mg. May be adequate and still give bone protection (implant can be cut in half)
Testosterone dose ... Low dose 75 mg, 50 mg or even 25 mg if androgen side effects occur (implant may be cut)
Location of Implant
The most common location for implants appears to be in the butt with subsequent implants going into alternating sides and into the same location as previously so that there's no additional scars after the first two. I have two small scars that are not easily seen - I've never been able to turn around far enough to see mine, and I have to point them out for others to notice. In one of the YouTube video's the scars are much larger, presumably due to the ability of the doctor.
Some doctors insert into the subprapubic region (ie groin), which I find quite disturbing. You'll also easily be able to see the scars. Some argue that this location is safer in that it avoids the risk of damage to the sciatic nerve; personally think that if the doctor can't be trusted to find the correct location it's time to find another doctor.
Beverly Cosgrove (who runs the massive TransHRT group on Facebook) makes this point in advocating for use of the effective more intra-muscular injection (not implant) to the buttocks
First, one reason doctors have for refusing to allow their transsexual patients to inject themselves is fear that they might hit the Sciatic nerve. This mistake is almost unheard of when injections are done by trans women – the scare stories are nearly all of novice nurses doing this – but it’s been a pretext used by doctors to deny injection as an option to their patients.
Trocars
A trocar is the surgical tool used to insert an implant/pellet. A reusable trocar can be used if the doctor has an autoclave is available, otherwise relativly cheap disposable torcars are available. In the long term reusable trocars are cheaper, but there's a much higher upfront cost (autoclaves are expensive and take space). There's other equipment required, and some suppliers sell a kit including trocar, syringe, needles, dressing, etc.
Trocars are available from
In Australia, transhub says
Estradiol pellets are avaiable as either 50mg or 100mg pellets, with between 50-100 mg generally considered a preferred dose. Pellets are replaced every 6-24 months, depending on the response of the individual1 The insertion procedure takes approximately 15 minutes, and requires an autoclaved or disposable trocar and cannula, such as those available here.
I have heard of doctors inserting an implants without a trocar, just using a scalpel blade, but this is a very crude method that is going to leave a substantial scar. Its also possible to insert an implant using a syringe, but again it seems like a bad idea. I'd avoid doctors who do this, unless there's no other choice.
reddit
TheraPellet Atraumatic Trocar
Uses a proprietary blunt tripped trocar which is said (by the inventor Dr. Charles P. Virden) to produce less tissue tramua. He's partnering with other doctors to offer this "patented atraumatic trocar." and has an as yet empty site atrocars.com.
Location
Site
YouTube
TheraPellet is exibiting at the AUA 2021 conference in Las Vegas September 10-13.
- https://www.aua2021.org/scientific-program/exhibitors.html - "Creators of the "Atraumatic Trocar" for hormone optimization for men and women. Preserves adipose tissues resulting in a much more positive patient experience and leaves the provider with more revenue due to decreased pellet cost."
The principal behind these seems to be the same as using blunt tipped canula's for cosmetic fat transfer and BBL
https://therapellet.com/atrocars-trocar-info - describes the usual 3.2mm, 4.5mm trocars, and also a larger 5.5mm trocar used to insert 300mg pellets. It also mentions the use of triamcinolone in the pellets, which is used by FarmaKeio/Evexipel. I assume these 300mg pellets are only testosterone, as much larger doses of testerone are required than estrogen and triamcinolone is intended to suppress extrusion which is far more common with testosterone.
Review sites
Patents
There's a trademark on "THERAPEL PELLET THERAPY", which is very similar to Virden's "TheraPellet". Even the graphic has some resmemblance. I don't know if there's any connection. The trademark is owned by Bonds Therapeutics LLC, also known
Pain
Before inserting the implant a local anesthetic of lidocaine is injected, otherwise it would no doubt be extremely painful. The "needle" of a trocar is very thick. With the local anesthetic the insertion of the implant is painless, however for some (me) the local anesthetic itself is extremely painful for a brief time as lidocaine is quite acidic.
See the wiki entry on lidocaine inejections
Tachyphylaxis
Doctors may warn you about tachyphylaxis when using implants. Its essentially a tolerance to estrogen, where you experience symptoms of low estrogen levels while actually having very high levels. Its easily avoided with the correct protocol and occurs if you get new implants based on symptoms (ie when you feel bad) rather than when your levels are actually low (using blood tests). Read more...
Dependance
An occasional argument by doctors against implants and higher levels of estrogen is that its addictive. Read more...
Low Estrogen Levels
Its possible to get implants and still have very low levels. My endo explained that to me that this can be due to them being encapsulated. On the positive side they will last a very long time when that happens.
reddit
Psychological Effects of High Estrogen
I find high estrogen levels of interest from a psychological point of view
- Depression is very common in the trans community and anything that helps safely alleviate that is valuable.
- There's people working on high level estrogen for the physical benefits, but I'm not aware of anyone looking into the psychological side.
- On of the benefits of implants is that its very easy to achieve high and stable estrogen blood levels.
- When the Sydney endocrinologist Dr Jon Hayes retired there were a small but significant number of trans women who were in serious psychological distress caused by the reduction in blood levels that then followed. These numbers and symptoms seem somewhat similar cis-women suffering PMDD.
Read more...
Estrogen Implants
reddit
Testosterone Implants
Australian endocrinologist Dr Jonathan Hayes has prescribed post-op women with low testosterone 50mg testosterone implants (the amount used in men is far higher). These implants are placed on top of the estrogen implants as they are more likely to extrude and you don't want them pushing the estrogen implants out.
Note that testosterone implants don't last as long as estrogen, so there's likely to be a shortfall in levels before the estrogen implant needs renewing.
Papers
- 2017 - Pharmacokinetics, Clinical Efficacy, Safety Profile, and Patient-Reported Outcomes in Patients Receiving Subcutaneous Testosterone Pellets 900 mg for Treatment of Symptoms Associated With Androgen Deficiency by Chris G. McMahon, Neil Shusterman, and Brian Cohen
- 2014 - A Review of Testosterone Pellets in the Treatment of Hypogonadism by Andrew McCullough
- 2011 - Outcomes with the "V" Implantation Technique vs. Standard Technique for Testosterone Pellet Therapy by William Conners, Kevin Flinn, and Abraham Morgentaler
- 2008 - Influence of implantation site and track geometry on the extrusion rate and pharmacology of testosterone implants by S. Kelleher, A. J. Conway, D. J. Handelsman - "We conclude that the hip site has a higher extrusion rate than the standard abdominal wall site but that track geometry does not increase the risk of extrusion. Neither implantation site, nor track geometry influenced either other adverse effects or the pharmacokinetics or pharmacodynamics of testosterone pellet implants."
- 1999 - Extrusion of testosterone pellets: a randomizedcontrolled clinical study by
S Kelleher, L Turner, C Howe, A J Conway, D J Handelsman
FTM
Testosterone implants are used trans-men, and searching /r/ftm for pellets will turn up some results.
reddit
Very bad experience using testopel - https://k-con.today/post/172598026877/whats-testopel
Progesterone Implants
Australian endocrinologist Dr Jonathan Hayes has prescribed progesterone implants, but they are prone to extrusion (about 10% at one point).
reddit
There's a discussion in the 1952 Ciba Foundation Symposium ‐ Steroid Hormone Administration (Book II of Colloquia on Endocrinology), Volume 3 page 279 on progesterone implants
We also noticed a tendency to extrusion, which is particularly noticeable for progesterone. One can almost go so far as to say that if one implants progesterone subcutaneously, it will certainly come out. Now that we have been using intramuscular implantation of progesterone with a trocar and cannula, we seldom get any extrusion at all.
Contraceptive Implants
These are completly different to the HRT implants described in the rest of the wiki, different drugs, size, and insertion location. Brands inludce Norplant, Jadelle (Norplant II), Implanon, Nexplanon, Sino-implant (II), Zarin, Femplant and Trust. They are of no use for transition.
Bovine Implants
Hormone implants has been used in cattle for around 60 year. I've seen them on eBay, but unlike implants for human use they have a solid non-absorbing core and are not at all suitable for people.
An example is the Elanco Compusdose with 21.1mg, 25.7mg and 43.9mg oestradiol-17ß.
- https://www.elanco.com.au/products-services/beef-cattle/products/cattle-compudose - "Compudose™ 100, 200 and 400 contain oestradiol-17ß, a naturally-occurring oestrogen. Each formulation consists of an inert silicone rubber core covered with a coating of oestradiol-medicated silicone rubber. The durable core helps in preventing crushing or breaking during implantation, ensuring consistent pay out and long-term performance."
Papers
Other
Papers
- 2021 - Low complication rates of testosterone and estradiol implants for androgen and estrogen replacement therapy in over 1 million procedures by Gary S. Donovitz - "This study is the largest reported retrospective study to evaluate the continuation and complication rates of T pellet implants. The safety of subcutaneous hormone pellet implants in men and women appears to be better than other routes of administration of bioidentical hormone replacement therapy."
- 2016 - Hormone therapy for transgender patients by Cécile A. Unger - this is only FTM testosterone implants
- 2011 - A guide to the treatment of depression in women by estrogens. by Studd
- 2009 - Subcutaneous testosterone pellet implant (Testopel) therapy for men with testosterone deficiency syndrome: a single-site retrospective safety analysis. - interesting paper on testosterone implants and their insertion. The relationship to estrogen implants is fairly clear.
- 2009 - Subcutaneous Testosterone Pellet Implant (Testopel®) Therapy for Men with Testosterone Deficiency Syndrome: A Single‐Site Retrospective Safety Analysis by Richard K. Cavender and Melissa Fairall in 2009 - this is for testosterone, but insertion appears to be much the same process as for estrogen
- 2002 - Supraphysiological concentrations of estradiol in menopausal women given repeated implant therapy do not adversely affect lipid profiles. by Pirwany IR, Sattar N, Greer IA, Packard CJ, Fleming R.
- 2001 - Influence of implantation site and track geometry on the extrusion rate and pharmacology of testosterone implants by S Kelleher, A J Conway, D J Handelsman - "We conclude that the hip site has a higher extrusion rate than the standard abdominal wall site but that track geometry does not increase the risk of extrusion. Neither implantation site, nor track geometry influenced either other adverse effects or the pharmacokinetics or pharmacodynamics of testosterone pellet implants."
- 1998 - An audit of oestrogen implant hormone replacement therapy. by Templeman C, Quinn D, Hansen R, Moreton T, Baber R.
- 1993 - Oestradiol and testosterone implants. by Studd JW, Smith RN, in 1993
- 1990 - Hormone implants and tachyphylaxis. by Garnett T, Studd J, Henderson A, Watson N, Savvas M, Leather A.
- 1990 - Pharmacokinetics and pharmacodynamics of testosterone pellets in man by
D J Handelsman, A J Conway, L M Boylan - shows levels with testosterone implants, and discusses SHBG, fibrosis, and Organon fused implants
- 1988 - Oestrogen implant overdose in 1988 by D H Barlow - "reports the persistence of
considerable serum oestradiol (E2) levels five years after the end of a series of oestradiol implant insertions in an oophorectomised woman. After three years her E2 level was about 2000 pmol/l. ... case represents considerable overdosage (200 mg every 3 months for 3 years)"
- 1983 - Treatment of menstrual migraine by oestradiol implants. by A L Magos, K J Zilkha, and J W Studd
- 1982 - Plasma Progesterone Levels Following Subdermal Implantation of Progesterone Pellets in Lactating Women by H B Croxatto, S Díaz, O Peralta, A M Salvatierra, A Brandeis
- 1981 - Hormonal Profiles In Postmenopausal Women After Therapy With Subcutaneous Implants by Margaret H. Thom, W. P. Collins, J. W. W. Studd
- 1980 - Procedures in practice. Hormone implantation. by Thom and Studd
- 1966 - Estrogenic substitution therapy with estradiol pellet implantation by Carl Jarolim, Lawrence I. Bernard, Herman A.Strauss
- 1953 - Endocrine Therapy in Gynecologic Disorders pages 410-424, by Herbert S. Kupperman, William E. Studdiford
Other
Doctors
Some doctors can be found by looking on the manufacturer's websites.
Australia
This is here.
Brazil
Silviane Pellegrinello
Key details
reddit
- Permanent HRT? by saturnintaurus in 2023 - "Mine was right above the butt, under the skin. Lasted 6 months. It’s incredibly convenient compared to any other options, but it was also very expensive... Dra. Silviane Pellegrinello in Cascavel, Paraná. She also does testosterone implants"
Canada
There's no evidence that either of these places work wiht trans people
Mexico
Arturo Martínez Díaz
I can't find out much about him, so not really sure what he does. However these is a YouTube video where he discusses pellets. Also on Facebook here.
Locations
Sites
http://www.geneticell.com.mx
YouTube
Beatriz Ojeda Suárez
There's a YouTube video of a doctor in Mexico discussing hormone pellets here, but I can't understand Spanish and can't work out anything much about her.
YouTube
New Zealand
reddit
South Africa
My Sexual Health
https://mysexualhealth.co.za
reddit
Spain
Clinicas Doctor Life
Do not do pellets for trans people, only intersex and cis women, see this reddit post - "I called Spain: "Clinicas Doctor Life" but they only accept cis/intersex women."
Key details
YouTube
UK
Estradiol pellets do exist in the UK, but only for cis women. I don't know who makes them and I don't think its possible for trans women to get them (2022), even though trans endo Leighton Seal has written "... oestrogen implant treatment is a safe and effective therapy with high patient satisfaction"
UK endocronologist Leighton Seal is influential in transgender HRT and has coauthored two papers on estradiol implants in trans women.
- https://www.stgeorges.nhs.uk/people/leighton-seal-2/ - "He has a subspecialty interest in andrology and testosterone disorders in men and women including Erectile Dysfunction, HRT in Males and Females and female testosterone treatment including hormone implant insertion. Mr Seal has extensive experience in Transgender medicine with the largest patient cohort in the UK and is recognised as a gender specialist by the gender recognition panel"
- https://gendercare.co.uk/leighton-seal.shtml - this trans specific site makes no mention of implants
British Menopause Society
- 2024-03-20 - Subcutaneous Hormone Implant Therapy - "Subcutaneous hormone implants are currently unavailable whilst the MHRA undertakes a review. Until recently, these implants were available from a small number of specialist centres in the UK and they are an important option for women who fail to respond to standard delivery routes. HRT implants, for this group of women, can result in better circulating estradiol levels than are achieved with oral or standard transdermal delivery routes, including patches, gel and spray, and this can improve symptom control. For reasons that are not always clear, some women do not respond to oral and transdermal HRT and oral HRT may be contraindicated due to risk factors for venous thromboembolism, which include obesity (BMI > 30). Many of the women who are prescribed HRT implants have experienced surgical menopause, and this includes younger women who often require higher levels of estradiol to fully alleviate symptoms, and also to protect against long term risks of early surgical menopause such as osteoporosis. Although the numbers are relatively small compared with the general population of menopausal women, for this small significant group, ensuring effective delivery of hormones with implants is really important. We feel strongly that hormone implants should remain available for the treatment of menopausal symptoms in women who do not respond favourably to other options1,2,3. Hormone implants have been used for more than fifty years and safety data are comparable with other non-oral routes of administration4,5. As long as appropriate doses are used at appropriate intervals, inappropriately high estradiol levels can be avoided. The value of HRT implants for women with suboptimal symptom control was the focus of two recent papers published in the BMS journal, Post Reproductive Health6,7. The British Menopause Society is happy to collaborate with MHRA, supporting their review of HRT implants."
- 2024-03-19 - NICE Guideline review – the BMS response - "As you are aware, the NICE guideline Menopause: diagnosis and management (NG23) is under review. The draft guideline was made available for consultation to stakeholders between 17 November 2023 and 5 January 2024. All members of the BMS board and medical advisory council undertook a detailed review of the draft guideline and submitted comprehensive feedback. This feedback was carefully evaluated and collated by Tim Hillard on behalf of the BMS and our 40-page completed form was submitted to NICE on 3 January, in advance of the NICE deadline. The BMS has serious concerns about the content of the consultation draft and the impact it will have on the treatment, health and wellbeing of women. We shared our concerns with other national and international specialist societies, and with Royal Colleges, who had similar views on the draft guideline. It was agreed that a joint letter expressing our concerns should be submitted to Professor Jonathan Benger, the Chief Medical Officer at NICE. This joint letter was sent on 18 January and a brief acknowledgement was received on 22 January. On Friday 15 March, we received further communication from Professor Benger requesting a meeting with the signatories of the letter. You should also be aware that one of the two topic advisors, together with one of the clinical experts, resigned from the Menopause Guideline Committee after the committee meeting in February. Neither felt that they could support the draft version of the reviewed NICE document. The revised guideline is due to be published on 13 May 2024. We trust that the concerns expressed by the BMS, by other specialist societies and Royal colleges and by the majority of stakeholders have been carefully considered and incorporated into the final version of the document."
Research
- 2021 - Efficacy of oestrogen implant in transwomen as hormone replacement therapy by Hareesh Joshi, Emre Gezer, Maricel Espina & Leighton Seal - "Oestrogen implant is effective in improving general well-being and libido in transwomen compared to other oestrogen delivery methods with average interval (>400 days) between implants."
- 2014 - Oestrogen implant improves symptoms of hypogonadism and lipid profile in transwomen by Ye Kyaw, Maricel Espina & Leighton Seal - "14 transwomen had 100 mg of oestradiol implant inserted subcutaneously in the anterior abdominal wall... 64.3% of the patients said implant therapy was better whereas 26% said it was the same. 1 patient (7%) said it was worse than previous treatment. There no complications in all 14 transwomen studied... This study is the first study to look into the use of oestrogen implant in transwomen. It not only improves symptoms but also improves lipid profile in transwomen. Therefore, oestrogen implant treatment is a safe and effective therapy with high patient satisfaction. It should be considered as a form of replacement in transwomen who do not respond to other forms of oestrogen therapy."
Buckinghamshire Formulary
- 585FM 1.2 Gender Dysphoria in Adults Shared Care Protocols by Leighton J Seal, page 3 "Ongoing Hormone Monitoring and Management Information Leaflet - Trans Feminine (v 1.0, 05/07/20" lists "Implants Estradiol", Dose 50-100mg, Frequency 6-24 monthly, Target range trough value 400-500 pmol/L, monitoring method "5 months after implant then repeated monthly until less than 500 (to inform secondarycare)", Maximum dose 100mg
Devon Partnership NHS Trust
USA
There's a list or doctors doing implants for trans people in the USA
Arizona
Tutera Medical
Location
Sites
California
Kristen Vierregger
Location
- 8081 Stanton Ave. Ste 300, Buena Park, California 90620
Doctors sites
reddit
YouTube
moderntranshormones.com
Review sites
Research
Richard Horowitz
Location
- Beverly Hills, California
Doctors sites
reddit
- reply to My 4 year journey in pictures. Transition complete! by Sassssssy in 2018 - "Unfortunately insurance doesn't cover pellets so I have to pay out of pocket. I was going to Dr. John O'Dea in Marina Del Ray but he wanted $1300 every 4-5 months! Dr. Richard Horowitz in Beverly Hills did mine for $375 last time."
review sites
Jian (Jim) Nan Ye
Transgender Map says Dr. Jim Ye does pellet implants.
Location
Sites
Review sites
John O'Dea
Location
Doctors site
reddit
Review sites
http://gendermedical.com/index.php/hormonal-articles/11-featured-hormonal-articles/350-trans-brain-trans-dupe - "When we treat transsexuals with long acting hormone pellets that effectively lower testosterone down to castrate levels, gender dysphoria vanishes only to reappear as these hormones drop below a certain threshold level, manifesting in the form of an increasingly distorted body image and diminished self-esteem & self-confidence. In contrast, patients who obtain injectable feminizing hormones that wax and wane, thus facilitating testosterone escapes, tend to be associated with persistence in their gender dysphoria even while the patient is being effectively feminized."
Susans
Matthew Lew
Key details
reddit
Florida
Clint Potter
His sites says he does BioTE implants, and this site says he does implants for transgender people.
Location
- 720 Goodlette Rd. N., Naples, FL 34102
Sites
Sherief Kamel
Location
Michigan
William Powers
Location
Doctors site
reddit
Tennessee
Mark T. Simpson
Mainly cis male/female, but some trans. Also see Dr Powers providers wiki.
Location
- The Wellness Clinic, 4513 Hixson Pike, Chattanooga, Tennessee
Providers sites
Ohio
Abraham Kuranga
Key details
Other
Texas
Raissa Behm
Key details
reddit
Washington
Lauren Gresham
Key details
reddit
Manufacturers
Australia
There are two main manufacturers of estrogen implants in Australia, Complementary Compounding Services (CCS) in Ballina and Stenlake in Sydney, plus a couple of others. CCS do make both 3mm and 4.5mm implants, and while Stenlake are known of the 4.5mm implants I believe they can also make the 3mm implants. The reason for either size are discussed above in Implant Technology.
See Compounding Pharmacies in Australia for more.
The 4.5mm implant size is a legacy of the international pharmaceutical company manufacturer (Organon Laboratories Limited) that stopped production in 2011. Stenlake produced compatible implants and the endo Dr Jonathan Hayes made a special smaller size for unknown reasons.
Stenlake's pellets are pure (no exipients) compressed estradiol, 4.5mm diameter.
This video shows an Australian transwomen having an implant inserted (not by Hayes). The size of the scar and technique are interesting, and personally I'll be asking any doctor I go to how they perform this procedure.
Dr Hayes used a different location and made a much smaller scar.
Australian Compounding pharmacies require a prescription from an Australian doctor. It is not possible to export using a foreign doctor.
Brazil
Hhominem Clinic
See the entry for Biopelle Medical in Ukraine as there seems to be some connection and I'm not sure what this clinic does.
New Zealand
There's a Facebook peer support group working towards getting implants into New Zealand, The Hormone Pellet Implant Club
reddit
Optimus Healthcare
Injections, not implants.
Key details
Discussion
reddit
Europe
Smartway Pharma
SottoPelle
Search here to find them in Europe, but I only looked at Spain.
There's not but these are in Spain - I don't know of they will treat trans people.
South Africa
Fagron Compounding Services
UK
Estradiol pellets do exist in the UK, but only for cis women. I don't know who makes them and I don't think its possible for trans women to get them (2022).
Ukraine
Biopell Medical
Its hard to tell if this is a Ukrainian company, or just a local sales site. There's some test on their page
Made by Hominem Clinic, R. Cubatao, 929 - sala 45, 46, 47 - Vila Mariana, Sao Paulo - SP, 04013-043, Rupublica Federativa do Brasil
Which would be
There's very little information on the biopell site, but there's various clinics in Ukraine that offer them
USA
If anyone knows anywhere else to find them please let me know.
Note that 503A make products to individual prescription and 503B make higher volume. As such 503B are probaly much less likley to produce custom produtcs (eg 100mg pellets if they don't already make them).
Advanced Pharmaceutical Technology Inc
https://opencorporates.com/companies/us_ny/4273337
Estrogen pellets 25mg, 50mg (Estra-25, Estra-50), testosterone 100mg, 200mg (Testo-100, Testo-200)
https://uspto.report/company/Advanced-Pharmaceutical-Technology-Inc
https://fda.report/Company/Advanced-Pharmaceutical-Technology-Inc
Anazao Health
This pdf Hormone Replacement Therapy Catalog lists estradiol pelleters for their 503B (batch compounding) facility in sizes of 6 mg, 10 mg, 12.5 mg, 15 mg, 18 mg, 20 mg, 22 mg, 25 mg, and testosterone/cholesterol pellets up to 200mg. Its not clear if their 503A (made to individual prescription) facility is any different.
Asteria Health
Belmar Pharmacy
reddit
BioTe
Compressed rather than heat fused according to this marketing document.
Carie Boyd's Prescription Shop
Complete Pharmaceutics
College Pharmacy
They make up to 50mg estradiol implants, ship to most USA states (but not Michigan). They can ship estradiol pellets internationally, depending on local laws, but not to Canada. They have shipped to Austalia (my endo has used them in the past). Their pellets are compressed, not heat fused.
reddit
Drug Crafters Custom Compounding Pharmacy
In Texas
Empower Pharmacy
Dosage Strengths of Estradiol Pellets 6 mg, 10 mg, 12.5 mg, 25 mg, 37.5 mg, 50 mg
YouTube
- 2021 - BHRT Pellet Procedure by Gray Erlacher, MD - Clinic 180 - note this shows a pellet in a glass ampule and its notable that there's no protective material inside the ampule, unlike the Organon pellets that uses sterile cotton wool. It wouldn't be surprising if these got damaged in shipping, but perhaps its not a problem as they only make small pellets.
Evexipel
FarmaKeio
Supply testosterone/triamcinolone pellets to Evexipel.
Innovation Compounding
Innovative Research of America
This company only supplies pellets for use in lab animals, and appear to specialise in fast release pellets of up to 90 days. They also 200mg estradiol pellets ($1274 per 25 = $51 each). They also do various custom pellets. These do not appear to be manufactured in the usual way human use pellets are made.
Master Pharm
Location
Pavillion Compounding Pharmacy
Pellecome
From their website
Pellecome’s estradiol pellets are available in the following strengths: 10 mg, 15 mg, 20 mg and 25 mg.
Pellecome’s progesterone pellets are available in the following strengths: 50 mg, 100 mg and 200 mg.
Pellecome’s testosterone pellets are available in the following strengths: 25 mg, 50 mg, 100 mg, 200 mg and 300 mg.
Pharmacy Solutions
This seems to be the same company as Solutions Pharmacy. Possibly a typo on their site?
Qualgen
Key details
They make 200mg testosterone pellets.
YouTube
There's a photo of a Qualgen pellet on this page of their site and it looks like it may be injection moulded, in which case they would be the only manufacturer I'm aware of who currently make heat fused pellets. However they do say the compress the pellets
Qualgen's pellets are formed by compressing bio-identical hormone ingredients into very small cylinders a little larger than a grain of rice, approximately 3 millimeters in diameter.
They also say
Qualgen's estradiol pellets are the purest bio-identical pellets on the market. Qualgen pellets are one of the only pellets that are 99.5% pure estradiol and are completely bio-identical. Qualgen uses no other binding agents or chemicals in our pellet production process that are not 100% natural bio-identicals.
This statement appears to contradict the photo on that same page showing a bottle containing a "Estradiol 18mg Pellet" with "USP .95% Stearic Acid NF". Presumably a very very careful intepretation would be that the stearic acid is "100% natual bio-identical".
Solutions Pharmacy
- States licesed in (not Michigan)
- https://solutionspharmacy.com/bio-identical-hormone-replacement-pellets/
- https://solutionspharmacy.com/physician-faq/
- Estradiol: 6mg, 10mg, 12.5mg, 15mg, 18mg, 20mg, 22mg, 25mg, 31mg, 37.5mg, 50mg, 75mg
- Testosterone: 12.5mg, 25mg, 37.5mg, 50mg, 87.5mg, 100mg, and fused 200mg
SottoPelle
Note that appearaneces to the contrary, SottoPelle do not manufacture pellets. I'm not sure what they actually do, but it appears to be more of a marketing organisation. Regardless, I'nm of the opinion that they have nothing of interest to the trans community.
reddit
Patents
Legal
- https://casetext.com/case/lyons-v-gorens - 06-04-2021, The SottoPelle defendants (collectively known as SottoPelle) promote the use of hormone replacement therapy using bioidentical hormone infused pellets (hormone pellets). The SottoPelle entities were managed by Dr. Gino Tutera, who passed away in 2015, and his wife, CarolAnn Tutera. Lyons was implanted with hormone pellets by Dr. Marsha Gorens, who attended SottoPelle educational conferences and was a SottoPelle Certified Physician. Lyons was later diagnosed and treated for breast cancer. As the case progressed, plaintiffs changed their theory of SottoPelle's liability. In plaintiffs' original complaint, they asserted that SottoPelle designed, manufactured, and sold hormone pellets. In a proposed amended complaint, plaintiffs asserted that SottoPelle was liable as an apparent manufacturer and under an enterprise theory. ... Responding to the question of whether any of the SottoPelle entities were the manufacturer of the hormone pellets used to treat Lyons, SottoPelle stated: "No. None of the SottoPelle Defendants are manufacturers of hormone pellets nor did they manufacture the pellets at issue. The SottoPelle Defendants have no knowledge of who manufactured the pellets at issue. The SottoPelle Defendants are familiar with Solutions Pharmacy in Tennessee as a manufacturer of pellets but cannot say for certain that they manufactured the pellets at issue in this case."
Superior Compounding
It looks like they dont' make them yet, but are looking into it with Dr Will Powers. See the reddit post.
Location
Sites
reddit
Wells Pharmacy Network
Westcliff Compounding Pharmacy
I can only find testosterone pellets on their website.
Key details
YouTube
Wiki Index
